KLHL12

Across TCGA patient cohorts, KLHL12 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLHL12-associated genes across cancer lineages are Annexin-1, FoxM1, and FOXO3a_pS318_S321. Each is linked with KLHL12 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLHL12-to-partner and partner-to-KLHL12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by KLHL12-low versus KLHL12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL12→partner) and Y-score (partner→KLHL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.464	+1.604	.018	.041	3	2
UCEC	FoxM1 →	+0.198	+1.415	.041	.046	3	1
UCEC	FOXO3a_pS318_S321 →	-0.097	-1.690	.039	.042	3	1
UCEC	IGFBP2 →	-0.668	-2.000	.006	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.142	-1.401	.025	.046	3	1
UCEC	JNK2 →	+0.176	+1.415	.018	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by KLHL12 expression — UCEC

Explore this box plot interactively →