KLHL12

Across TCGA patient cohorts, KLHL12 protein abundance is significantly associated with the RNA expression of many other genes, with 19,090 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible KLHL12-associated genes across cancer lineages are SLC25A1, FTSJ3, and UTP18. Each is linked with KLHL12 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLHL12-to-partner and partner-to-KLHL12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KLHL12 versus SLC25A1 in BRCA, with a Pearson correlation of 0.22.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLHL12→partner) and Y-score (partner→KLHL12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC25A1 →	+0.614	+0.220	<.001	<.001	3	2
LSCC	FTSJ3 →	+0.543	+0.300	<.001	<.001	3	2
LSCC	UTP18 →	+0.573	+0.246	<.001	<.001	3	2
LSCC	DDX39A →	+0.677	+0.249	<.001	<.001	3	2
UCEC	C20orf85 →	-2.275	-0.205	.001	.002	3	2
LSCC	TACO1 →	+0.648	+0.304	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,090 associations by consensus.

KLHL12 vs SLC25A1 — BRCA

Explore this scatter interactively →