KLHL12

Across TCGA pan-cancer cohorts, KLHL12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated KLHL12 data layer compared with 20 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher KLHL12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated KLHL12 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

LUAD, UCEC, and LSCC are the cancer types where KLHL12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	II,III,IV	0.300	0.787	.001	14	view →
UCEC	OS	Tertile	All	0.968	0.764	.020	12	view →
LSCC	DFS	Median	II,III,IV	0.841	0.557	.020	9	view →
CCRCC	DFS	Quartile	All	1.000	0.710	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

KLHL12–LUAD (OS)

Open the LUAD breakdown →