Q-omics provides the consensus-scored KIAA1586 profile across patient tissues and cancer cell-line models. KIAA1586 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, KIAA1586 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, KIAA1586 RNA expression shows 20,890 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRP, HNSC, and ACC as cancer lineages where KIAA1586 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KIAA1586 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KIAA1586 survival associations across molecular data types. KIAA1586 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (7) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KIAA1586 RNA expression–survival associations across cancer types. High KIAA1586 expression shows unfavorable associations in KIRP, KICH, ACC and MESO, but favorable associations in UCS and LUAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for KIAA1586 RNA expression.
This table summarizes KIAA1586 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for KIAA1586. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KIAA1586 shows lower tumor expression in THCA and KICH and higher tumor expression in HNSC, KIRC, LIHC and KIRP. The HNSC box plot shows higher KIAA1586 RNA expression in tumor versus normal tissue (log2 FC = +0.748, t-test p < 0.001).
This table shows molecular features associated with KIAA1586 in patient tissues and cancer cell lines. In patient samples, KIAA1586 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, KIAA1586 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in LIVER and LARGE_INTESTINE.
