KIAA1586

Across TCGA patient cohorts, KIAA1586 mutation is significantly associated with the RNA expression of many other genes, with 2,663 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1586-associated genes across cancer lineages are RNA5SP411, MELK, and C1orf174. Each is linked with KIAA1586 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIAA1586-to-partner and partner-to-KIAA1586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by KIAA1586-low versus KIAA1586-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1586→partner) and Y-score (partner→KIAA1586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.779	+1.683	<.001	.002	3	3
UCEC	MELK →	+0.632	+3.711	.003	<.001	3	3
UCEC	C1orf174 →	+0.413	+2.628	<.001	<.001	3	3
COAD	MIR3135A →	+0.549	+3.602	<.001	.003	3	3
STAD	MIR1179 →	+0.399	+3.782	<.001	.007	3	3
LIHC	OR6M1 →	+0.023	+4.149	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,663 associations by consensus.

RNA5SP411 by KIAA1586 expression — UCEC

Explore this box plot interactively →