KIAA1586

Across TCGA patient cohorts, KIAA1586 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA1586-associated genes across cancer lineages are PCNA, Annexin-1, and Caspase-7-cleavedD198. Each is linked with KIAA1586 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA1586-to-partner and partner-to-KIAA1586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by KIAA1586-low versus KIAA1586-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1586→partner) and Y-score (partner→KIAA1586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.346	+2.938	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.682	+3.019	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.566	+1.604	.005	.021	3	2
UCEC	EGFR_pY1068 →	-0.223	-2.502	.010	.001	3	1
UCEC	EGFR_pY1173 →	+0.067	+1.467	.016	.015	3	1
UCEC	ERK2 →	+0.181	+2.222	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PCNA by KIAA1586 expression — UCEC

Explore this box plot interactively →