KIAA1586

Across TCGA cell cohorts, KIAA1586 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,321 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIAA1586-associated GO terms across cancer lineages are Negative regulation of metaphase/anaphase transition of cell cycle, Negative regulation of chromosome separation, and Regulation of chromosome organization. Each is linked with KIAA1586 in more than 15 cancer types. Because this analysis shows association rather than direction, both KIAA1586-to-partner and partner-to-KIAA1586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of metaphase/anaphase transition of cell cycle grouped by KIAA1586-low versus KIAA1586-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1586→partner) and Y-score (partner→KIAA1586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of metaphase/anaphase transition of cell cycle →	+0.134	+0.622	.002	.005	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of chromosome separation →	+0.134	+0.622	.002	.005	3	16
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome organization →	+0.079	+0.819	.001	.001	3	16
PANCREAS	Negative regulation of mitotic sister chromatid separation →	+0.146	+0.868	<.001	.003	3	15
PANCREAS	Negative regulation of sister chromatid segregation →	+0.146	+0.868	<.001	.003	3	15
PANCREAS	Negative regulation of mitotic sister chromatid segregation →	+0.146	+0.868	<.001	.003	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,321 associations by consensus.

Negative regulation of metaphase/anaphase transition of cell cycle by KIAA1586 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →