KIAA1586

Across TCGA cell cohorts, KIAA1586 mutation is significantly associated with the RNA expression of many other genes, with 353 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KIAA1586-associated genes across cancer lineages are CENPM, SGSM3, and BLOC1S6. Each is linked with KIAA1586 in more than 1 cancer types. Because this analysis shows association rather than direction, both KIAA1586-to-partner and partner-to-KIAA1586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by KIAA1586-low versus KIAA1586-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA1586→partner) and Y-score (partner→KIAA1586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPM →	+0.833	+3.364	<.001	.002	3	1
LARGE_INTESTINE	SGSM3 →	+0.909	+3.364	<.001	.002	3	1
LARGE_INTESTINE	BLOC1S6 →	+0.461	+3.364	.005	.002	3	1
LARGE_INTESTINE	INTS10 →	+0.594	+3.364	.008	.002	3	1
LARGE_INTESTINE	TRIM37 →	+0.678	+3.364	.001	.002	3	1
LARGE_INTESTINE	UBE2D3 →	+0.478	+3.067	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

CENPM by KIAA1586 expression — LARGE_INTESTINE

Explore this box plot interactively →