katanin regulatory subunit B1Genealiases: KAT · LIS6
Q-omics provides the consensus-scored KATNB1 profile across patient tissues and cancer cell-line models. KATNB1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, KATNB1 is differentially expressed in 16, with the highest sampling consensus in KIRP. Additionally, KATNB1 protein abundance shows 24,728 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, KIRP, and GBM as cancer lineages where KATNB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KATNB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KATNB1 survival associations across molecular data types. KATNB1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (4) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KATNB1 RNA expression–survival associations across cancer types. High KATNB1 expression shows unfavorable associations in KIRC, BLCA and LIHC, but favorable associations in UCEC, SCLC and UVM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for KATNB1 RNA expression.
This table summarizes KATNB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 9. The strongest signals are observed in KIRP for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for KATNB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KATNB1 shows higher tumor expression in KIRP, COAD, BLCA, LIHC, HNSC and KIRC. The KIRP box plot shows higher KATNB1 RNA expression in tumor versus normal tissue (log2 FC = +1.162, t-test p < 0.001).
This table shows molecular features associated with KATNB1 in patient tissues and cancer cell lines. In patient samples, KATNB1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, KATNB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in OVARY and BLOOD_Leukemia.
