KATNB1

Across TCGA pan-cancer cohorts, KATNB1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of KATNB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where KATNB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KATNB1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, COAD, and BLCA are the cancer types where KATNB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KATNB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	IV	+1.162	<.001	11	view →
COAD	All	IV	+1.017	<.001	11	view →
BLCA	All	III,IV	+0.917	<.001	11	view →
LIHC	Female	II,III,IV	+1.256	<.001	9	view →
HNSC	Male	III,IV	+0.678	<.001	8	view →
KIRC	Female	All	+0.355	.001	8	view →
THCA	All	All	−0.193	<.001	7	view →
STAD	Male	II,III,IV	+0.766	<.001	5	view →
KICH	All	All	−0.491	<.001	5	view →
PAAD	All	All	+0.362	.022	4	view →
CHOL	All	All	+2.161	<.001	3	view →
READ	All	All	+0.693	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

KATNB1–KIRP

Open the KIRP breakdown →