KATNB1

Across TCGA patient cohorts, KATNB1 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KATNB1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with KATNB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KATNB1-to-partner and partner-to-KATNB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by KATNB1-low versus KATNB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KATNB1→partner) and Y-score (partner→KATNB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.094	-3.295	.014	.009	3	1
UCEC	A-Raf_pS299 →	-0.104	-1.678	.023	.023	3	1
UCEC	FOXO3a_pS318_S321 →	-0.124	-1.874	.009	.049	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.417	+1.884	.032	.030	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-3.000	.001	<.001	3	1
UCEC	NF-kB-p65_pS536 →	-0.369	-2.321	.034	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

14-3-3_beta by KATNB1 expression — UCEC

Explore this box plot interactively →