immunoglobulin heavy variable 4-34Genealiases: IGHV434 · VH
Q-omics provides the consensus-scored IGHV4-34 profile across patient tissues and cancer cell-line models. IGHV4-34 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, IGHV4-34 is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, IGHV4-34 RNA expression shows 13,865 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, COAD, and LSCC as cancer lineages where IGHV4-34 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for IGHV4-34 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes IGHV4-34 survival associations across molecular data types. IGHV4-34 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible IGHV4-34 RNA expression–survival associations across cancer types. High IGHV4-34 expression shows unfavorable associations in KIRP, but favorable associations in HNSC, SKCM, UCEC, BRCA and SARC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for IGHV4-34 RNA expression.
This table summarizes IGHV4-34 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in COAD for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for IGHV4-34. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. IGHV4-34 shows lower tumor expression in COAD, PAAD and READ and higher tumor expression in LUAD, KIRC and BLCA. The COAD box plot shows higher IGHV4-34 RNA expression in normal versus tumor tissue (log2 FC = −2.082, t-test p < 0.001).
This table shows molecular features associated with IGHV4-34 in patient tissues and cancer cell lines. In patient samples, IGHV4-34 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
