Across TCGA pan-cancer cohorts, IGHV4-34 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated IGHV4-34 data layer compared with 22 for mass-spec protein and 3 for mutation status.
The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher IGHV4-34 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated IGHV4-34 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.
CCRCC, LUAD, and PDAC are the cancer types where IGHV4-34 mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.