IGHV4-34

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, IGHV4-34 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,865 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IGHV4-34-associated proteins across cancer lineages are PTPN7, MZB1, and ARHGAP45. Each is linked with IGHV4-34 in more than 9 cancer types. Because this analysis shows association rather than direction, both IGHV4-34-to-partner and partner-to-IGHV4-34 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-34→partner) and Y-score (partner→IGHV4-34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
OVPTPN7 →+0.603+2.645.004<.001310
OVMZB1 →+1.564+3.175<.001<.001310
GBMARHGAP45 →+0.537+1.401<.001<.001310
BRCAIL16 →+0.648+2.997<.001<.001310
BRCADOCK2 →+0.605+2.794<.001<.001310
OVHCLS1 →+0.556+2.960<.001<.001310
Each partner links to its Q-omics profile. Showing the 6 strongest of 13,865 associations by consensus.

Exploration