Across TCGA patient cohorts, IGHV4-34 protein abundance is significantly associated with the RNA expression of many other genes, with 7,524 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IGHV4-34-associated genes across cancer lineages are NCF4, P2RX1, and JCHAIN. Each is linked with IGHV4-34 in more than 6 cancer types. Because this analysis shows association rather than direction, both IGHV4-34-to-partner and partner-to-IGHV4-34 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-34→partner) and Y-score (partner→IGHV4-34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NCF4 →	+1.094	+1.564	.002	<.001	3	7
UCEC	P2RX1 →	+0.771	+1.007	<.001	<.001	3	7
OV	JCHAIN →	+3.333	+1.113	.001	.002	3	7
OV	CD53 →	+1.319	+1.274	.002	<.001	3	7
OV	JAML →	+1.018	+1.267	.001	<.001	3	7
OV	IGKC →	+4.631	+1.193	.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,524 associations by consensus.

Exploration

IGHV4-34 survival (RNA) · tumor vs normal (RNA) · all IGHV4-34 data types