Across TCGA patient cohorts, IGHV4-34 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IGHV4-34-associated genes across cancer lineages are RNU6-206P, MIR4507, and AQP7P4. Each is linked with IGHV4-34 in more than 2 cancer types. Because this analysis shows association rather than direction, both IGHV4-34-to-partner and partner-to-IGHV4-34 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IGHV4-34→partner) and Y-score (partner→IGHV4-34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-206P →	+0.372	+5.245	<.001	.002	3	3
HNSC	MIR4507 →	+0.685	+4.748	<.001	.003	3	2
HNSC	AQP7P4 →	+0.067	+5.111	<.001	.004	3	2
UCEC	RNU1-57P →	+0.466	+5.470	<.001	.001	3	2
UCEC	SNORD116-23 →	+0.924	+4.169	<.001	.002	3	2
UCEC	RNU6-906P →	+0.781	+3.671	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

Exploration

IGHV4-34 survival (RNA) · tumor vs normal (RNA) · all IGHV4-34 data types