Q-omics provides the consensus-scored HLA-DOA profile across patient tissues and cancer cell-line models. HLA-DOA expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, HLA-DOA is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, HLA-DOA RNA expression shows 21,353 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight SKCM, KIRC, and LSCC as cancer lineages where HLA-DOA shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for HLA-DOA — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes HLA-DOA survival associations across molecular data types. HLA-DOA RNA expression shows survival associations in the most cancer types (20), followed by mutation status (7) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible HLA-DOA RNA expression–survival associations across cancer types. High HLA-DOA expression shows unfavorable associations in UVM and LGG, but favorable associations in SKCM, KIRC, HNSC and LUAD. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for HLA-DOA RNA expression.
This table summarizes HLA-DOA tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for HLA-DOA. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. HLA-DOA shows lower tumor expression in KICH, LUAD, COAD and LUSC and higher tumor expression in KIRC and THCA. The KIRC box plot shows higher HLA-DOA RNA expression in tumor versus normal tissue (log2 FC = +1.612, t-test p < 0.001).
This table shows molecular features associated with HLA-DOA in patient tissues and cancer cell lines. In patient samples, HLA-DOA shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, HLA-DOA RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BLOOD_Leukemia.
