Across TCGA cell cohorts, HLA-DOA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,489 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DOA-associated GO terms across cancer lineages are Dendritic cell antigen processing and presentation, Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, and Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Each is linked with HLA-DOA in more than 10 cancer types. Because this analysis shows association rather than direction, both HLA-DOA-to-partner and partner-to-HLA-DOA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOA→partner) and Y-score (partner→HLA-DOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Dendritic cell antigen processing and presentation →	+1.608	+0.430	<.001	.004	3	11
SKIN	Regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.412	+2.457	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation →	+1.525	+0.414	<.001	.005	3	9
LUNG_NSCLC_LUSC	Positive regulation of dendritic cell antigen processing and presentation →	+1.876	+0.382	<.001	.001	3	9
CNS	Positive regulation of antigen processing and presentation →	+1.416	+1.223	<.001	.004	3	9
LUNG_NSCLC_LUSC	MHC class II protein complex assembly →	-0.283	-0.262	.003	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,489 associations by consensus.

Exploration

HLA-DOA survival (RNA) · tumor vs normal (RNA) · all HLA-DOA data types