Across TCGA patient cohorts, HLA-DOA mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible HLA-DOA-associated genes across cancer lineages are TAZ, C-Raf, and Tuberin_pT1462. Each is linked with HLA-DOA in more than 1 cancer types. Because this analysis shows association rather than direction, both HLA-DOA-to-partner and partner-to-HLA-DOA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOA→partner) and Y-score (partner→HLA-DOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TAZ →	-0.195	-3.000	.017	.037	3	1
UCEC	C-Raf →	+0.187	+3.000	.023	.036	3	1
UCEC	Tuberin_pT1462 →	+0.349	+2.817	.009	.036	2	1
UCEC	MEK1 →	+0.452	+3.000	.032	.037	1	1
UCEC	Tuberin →	+0.541	+3.000	<.001	.037	1	1
UCEC	Caspase-8 →	-0.308	-3.000	.034	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

HLA-DOA survival (RNA) · tumor vs normal (RNA) · all HLA-DOA data types