Across TCGA cell cohorts, HLA-DOA RNA expression is significantly associated with the RNA expression of many other genes, with 5,323 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible HLA-DOA-associated genes across cancer lineages are HLA-DPB1, HLA-DRA, and HLA-DMB. Each is linked with HLA-DOA in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DOA-to-partner and partner-to-HLA-DOA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOA→partner) and Y-score (partner→HLA-DOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HLA-DPB1 →	+4.581	+2.886	<.001	<.001	3	10
BLOOD_Myeloma	HLA-DRA →	+6.023	+2.723	<.001	<.001	3	9
BLOOD_Myeloma	HLA-DMB →	+4.262	+3.279	<.001	<.001	3	9
BLOOD_Myeloma	HLA-DRB1 →	+6.677	+3.258	<.001	<.001	3	8
BLOOD_Myeloma	HLA-DPA1 →	+4.980	+2.089	<.001	<.001	3	7
BLOOD_Leukemia	CIITA →	+3.025	+2.837	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,323 associations by consensus.

Exploration

HLA-DOA survival (RNA) · tumor vs normal (RNA) · all HLA-DOA data types