Across TCGA patient cohorts, HLA-DOA RNA expression is significantly associated with the protein abundance of many other proteins, with 21,353 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible HLA-DOA-associated proteins across cancer lineages are CD74, CYRIB, and DEF6. Each is linked with HLA-DOA in more than 9 cancer types. Because this analysis shows association rather than direction, both HLA-DOA-to-partner and partner-to-HLA-DOA results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (HLA-DOA→partner) and Y-score (partner→HLA-DOA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD74 →	+0.988	+1.944	<.001	<.001	3	10
OV	CYRIB →	+0.354	+1.344	.007	.002	3	10
GBM	DEF6 →	+0.625	+1.226	<.001	<.001	3	10
GBM	DOCK2 →	+0.744	+1.398	<.001	<.001	3	10
GBM	AIF1 →	+0.967	+1.472	<.001	<.001	3	10
UCEC	EVL →	+0.814	+1.561	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,353 associations by consensus.

Exploration

HLA-DOA survival (RNA) · tumor vs normal (RNA) · all HLA-DOA data types