Q-omics provides the consensus-scored H1-7 profile across patient tissues and cancer cell-line models. H1-7 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, H1-7 is differentially expressed in 14, with the highest sampling consensus in LUAD. Additionally, H1-7 RNA expression shows 15,270 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, LUAD, and THYM as cancer lineages where H1-7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for H1-7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes H1-7 survival associations across molecular data types. H1-7 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible H1-7 RNA expression–survival associations across cancer types. High H1-7 expression shows unfavorable associations in THCA and DLBC, but favorable associations in HNSC, PAAD, ACC and SARC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for H1-7 RNA expression.
This table summarizes H1-7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for H1-7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. H1-7 shows lower tumor expression in LUAD, KIRP, BLCA, UCEC, LUSC and KICH. The LUAD box plot shows higher H1-7 RNA expression in normal versus tumor tissue (log2 FC = −0.285, t-test p < 0.001).
This table shows molecular features associated with H1-7 in patient tissues and cancer cell lines. In patient samples, H1-7 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, H1-7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BREAST.
