Across TCGA cell cohorts, H1-7 mutation is significantly associated with the mutation status of many other genes, with 1,707 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H1-7-associated genes across cancer lineages are AHCYL2, PKNOX2, and NDN. Each is linked with H1-7 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-7-to-partner and partner-to-H1-7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-7→partner) and Y-score (partner→H1-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AHCYL2 →	+4.321	+5.285	.005	.005	1	3
BLOOD_Leukemia	PKNOX2 →	+4.736	+5.560	.003	.003	1	3
BLOOD_Leukemia	NDN →	+4.321	+5.285	.005	.005	1	3
BLOOD_Lymphoma	L1CAM →	+4.584	+4.584	.007	.007	1	3
LARGE_INTESTINE	GANAB →	+3.459	+3.459	.006	.006	1	3
LARGE_INTESTINE	ZSCAN25 →	+3.459	+3.459	.006	.006	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,707 associations by consensus.

Exploration

H1-7 survival (RNA) · tumor vs normal (RNA) · all H1-7 data types