Across TCGA pan-cancer cohorts, H1-7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of H1-7’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where H1-7 RNA is repressed in tumor relative to normal tissue. In most cancer types H1-7 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.
LUAD, KIRP, and BLCA are the cancer types where H1-7 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-7 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.