Across TCGA pan-cancer cohorts, H1-7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated H1-7 data layer compared with 6 for mutation status.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H1-7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated H1-7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.
HNSC, PAAD, and THCA are the cancer types where H1-7 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.