Across TCGA cell cohorts, H1-7 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible H1-7-associated genes across cancer lineages are OR1L6, CDH20, and TRARG1. Each is linked with H1-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-7-to-partner and partner-to-H1-7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-7→partner) and Y-score (partner→H1-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L6 →	+0.035	+5.029	<.001	.006	3	2
LARGE_INTESTINE	CDH20 →	+0.136	+3.766	<.001	.004	3	1
LARGE_INTESTINE	TRARG1 →	+0.022	+3.345	<.001	.007	3	1
LARGE_INTESTINE	NPY2R →	+0.004	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	GAGE12H →	+1.799	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

H1-7 survival (RNA) · tumor vs normal (RNA) · all H1-7 data types