H1-7

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, H1-7 mutation is significantly associated with the RNA expression of many other genes, with 857 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-7-associated genes across cancer lineages are CCL3, RNU6-450P, and CYB5RL. Each is linked with H1-7 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-7-to-partner and partner-to-H1-7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-7→partner) and Y-score (partner→H1-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCCL3 →+1.214+3.732<.001<.00132
UCECRNU6-450P →+0.509+2.536.005.00132
UCECCYB5RL →+0.358+2.638.003.00532
UCECSUCLG2-AS1 →+0.382+2.670<.001.00532
UCECRN7SL340P →+0.176+3.351<.001.00432
UCECPOLE2 →+0.767+2.606<.001.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 857 associations by consensus.

Exploration