RNA, U6 small nuclear 450, pseudogeneGenealiases: []
Q-omics provides the consensus-scored RNU6-450P profile across patient tissues and cancer cell-line models. RNU6-450P expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in READ. Among the 18 cancer types available for tumor–normal comparison, RNU6-450P is differentially expressed in 5, with the highest sampling consensus in STAD. Additionally, RNU6-450P RNA expression shows 6,627 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight READ, and STAD as cancer lineages where RNU6-450P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-450P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-450P survival associations across molecular data types. RNU6-450P RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-450P RNA expression–survival associations across cancer types. High RNU6-450P expression shows unfavorable associations in READ, KIRC, ACC, KICH and UVM, but favorable associations in HNSC. The READ Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .004). Together, the overview and detailed table identify READ as the clearest survival context for RNU6-450P RNA expression.
This table summarizes RNU6-450P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in STAD for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-450P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-450P shows lower tumor expression in COAD, THCA and KICH and higher tumor expression in STAD and PRAD. The STAD box plot shows higher RNU6-450P RNA expression in tumor versus normal tissue (log2 FC = +0.543, t-test p = .002).
This table shows molecular features associated with RNU6-450P in patient tissues and cancer cell lines. In patient samples, RNU6-450P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
