Across TCGA patient cohorts, H1-7 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-7-associated genes across cancer lineages are ASNS, MSH2, and EGFR_pY1068. Each is linked with H1-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H1-7-to-partner and partner-to-H1-7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-7→partner) and Y-score (partner→H1-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.543	+3.169	.006	.020	3	2
SKCM	MSH2 →	+0.314	+2.824	.019	.036	3	1
UCEC	EGFR_pY1068 →	-0.414	-3.169	.002	.020	3	1
UCEC	FoxM1 →	+0.311	+3.169	.028	.020	3	1
UCEC	ACC_pS79 →	+0.431	+3.169	.023	.020	3	1
UCEC	Annexin-1 →	+0.774	+3.169	.007	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

H1-7 survival (RNA) · tumor vs normal (RNA) · all H1-7 data types