G protein subunit alpha i1Genealiases: Gi · HG1B · NEDHISB
Q-omics provides the consensus-scored GNAI1 profile across patient tissues and cancer cell-line models. GNAI1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, GNAI1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, GNAI1 protein abundance shows 28,351 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight STAD, COAD, and GBM as cancer lineages where GNAI1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GNAI1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GNAI1 survival associations across molecular data types. GNAI1 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GNAI1 RNA expression–survival associations across cancer types. High GNAI1 expression shows unfavorable associations in STAD, LUAD, CESC and KICH, but favorable associations in LGG and KIRC. The STAD Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify STAD as the clearest survival context for GNAI1 RNA expression.
This table summarizes GNAI1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for GNAI1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GNAI1 shows lower tumor expression in COAD, KIRC, KICH and THCA and higher tumor expression in HNSC and LIHC. The COAD box plot shows higher GNAI1 RNA expression in normal versus tumor tissue (log2 FC = −1.774, t-test p < 0.001).
This table shows molecular features associated with GNAI1 in patient tissues and cancer cell lines. In patient samples, GNAI1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, GNAI1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BREAST.
