GNAI1

Across TCGA patient cohorts, GNAI1 mutation is significantly associated with the RNA expression of many other genes, with 1,508 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GNAI1-associated genes across cancer lineages are RNU6-249P, RN7SKP286, and RNU6-164P. Each is linked with GNAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAI1-to-partner and partner-to-GNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-249P grouped by GNAI1-low versus GNAI1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI1→partner) and Y-score (partner→GNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-249P →	+0.456	+4.654	<.001	.004	3	2
UCEC	RN7SKP286 →	+0.044	+3.973	<.001	.006	3	2
LUSC	RNU6-164P →	+0.278	+5.309	<.001	.003	3	2
BLCA	IGHD5-12 →	+1.042	+4.495	<.001	.001	3	2
CESC	DPPA2 →	+0.678	+4.364	<.001	.006	3	1
CESC	NF1P5 →	+0.077	+5.144	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,508 associations by consensus.

RNU6-249P by GNAI1 expression — HNSC

Explore this box plot interactively →