GNAI1

Across TCGA pan-cancer cohorts, GNAI1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GNAI1 data layer compared with 20 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher GNAI1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GNAI1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

COAD, UCEC, and LGG are the cancer types where GNAI1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.150	0.691	.001	10	view →
UCEC	DFS	Median	All	1.000	0.627	.017	10	view →
LGG	DFS	Median	All	0.185	0.832	<.001	6	view →
LIHC	OS	Median	II,III,IV	0.118	0.716	.003	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

GNAI1–COAD (DFS)

Open the COAD breakdown →