GNAI1

Across TCGA pan-cancer cohorts, GNAI1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GNAI1 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GNAI1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated GNAI1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where GNAI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.776	0.533	.002	33	view →
LUAD	DFS	Median	II,III,IV	0.773	1.000	.005	19	view →
LSCC	DFS	Median	II,III,IV	1.000	0.825	.002	10	view →
CCRCC	DFS	Median	III,IV	1.000	0.809	.012	9	view →
PDAC	DFS	Median	All	0.360	0.530	.038	6	view →
UCEC	OS	Tertile	III,IV	0.345	1.000	.036	4	view →
GBM	DFS	Tertile	All	0.856	0.637	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GNAI1–HNSC (DFS)

Open the HNSC breakdown →