GNAI1

Across TCGA patient cohorts, GNAI1 protein abundance is significantly associated with the RNA expression of many other genes, with 12,104 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GNAI1-associated genes across cancer lineages are SEPTIN4, LMOD1, and RBMS3. Each is linked with GNAI1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GNAI1-to-partner and partner-to-GNAI1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GNAI1 versus SEPTIN4 in GBM, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI1→partner) and Y-score (partner→GNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEPTIN4 →	+0.869	+0.740	<.001	<.001	3	6
COAD	LMOD1 →	+1.496	+0.462	<.001	<.001	3	6
CCRCC	RBMS3 →	+0.598	+0.296	<.001	<.001	3	5
HNSC	P3H2 →	+1.747	+0.614	<.001	.001	3	5
GBM	FEZ1 →	+0.797	+0.916	<.001	<.001	3	5
CCRCC	RASGRF2 →	+0.595	+0.360	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,104 associations by consensus.

GNAI1 vs SEPTIN4 — GBM

Explore this scatter interactively →