GNAI1

Across TCGA cell cohorts, GNAI1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,304 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GNAI1-associated GO terms across cancer lineages are Positive regulation of relaxation of muscle, Positive regulation of relaxation of smooth muscle, and Regulation of relaxation of smooth muscle. Each is linked with GNAI1 in more than 19 cancer types. Because this analysis shows association rather than direction, both GNAI1-to-partner and partner-to-GNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of relaxation of muscle grouped by GNAI1-low versus GNAI1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI1→partner) and Y-score (partner→GNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Positive regulation of relaxation of muscle →	+1.915	+3.826	<.001	<.001	3	20
BLOOD_Leukemia	Positive regulation of relaxation of smooth muscle →	+1.852	+3.912	<.001	<.001	3	20
OVARY	Regulation of relaxation of smooth muscle →	+0.277	+1.300	<.001	<.001	3	14
BLOOD_Leukemia	Adenylate cyclase-inhibiting serotonin receptor signaling pathway →	+1.644	+3.206	<.001	<.001	3	12
KIDNEY	Positive regulation of cholesterol biosynthetic process →	+0.094	+1.189	<.001	.008	3	10
KIDNEY	Positive regulation of sterol biosynthetic process →	+0.094	+1.189	<.001	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,304 associations by consensus.

Positive regulation of relaxation of muscle by GNAI1 expression — BLOOD_Leukemia

Explore this box plot interactively →