GNAI1

Across TCGA cell cohorts, GNAI1 mutation is significantly associated with the RNA expression of many other genes, with 49 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GNAI1-associated genes across cancer lineages are ZIC3, CFHR2, and PZP. Each is linked with GNAI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GNAI1-to-partner and partner-to-GNAI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC3 grouped by GNAI1-low versus GNAI1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GNAI1→partner) and Y-score (partner→GNAI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZIC3 →	+0.529	+4.867	<.001	.009	3	2
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	2
BLOOD_Myeloma	PZP →	+0.036	+4.807	<.001	.006	3	1
BLOOD_Myeloma	TAAR6 →	+0.043	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SPATA3 →	+0.080	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CLEC19A →	+0.133	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ZIC3 by GNAI1 expression — BLOOD_Lymphoma

Explore this box plot interactively →