glucocorticoid modulatory element binding protein 1Genealiases: P96PIF · PIF96
Q-omics provides the consensus-scored GMEB1 profile across patient tissues and cancer cell-line models. GMEB1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, GMEB1 is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, GMEB1 RNA expression shows 20,144 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and HNSC as cancer lineages where GMEB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GMEB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GMEB1 survival associations across molecular data types. GMEB1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (5) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GMEB1 RNA expression–survival associations across cancer types. High GMEB1 expression shows unfavorable associations in ACC, LIHC and KICH, but favorable associations in SCLC, UCS and KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for GMEB1 RNA expression.
This table summarizes GMEB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for GMEB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GMEB1 shows lower tumor expression in KICH and higher tumor expression in HNSC, LIHC, STAD, CHOL and BLCA. The HNSC box plot shows higher GMEB1 RNA expression in tumor versus normal tissue (log2 FC = +0.562, t-test p < 0.001).
This table shows molecular features associated with GMEB1 in patient tissues and cancer cell lines. In patient samples, GMEB1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, GMEB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BLOOD_Lymphoma.
