GMEB1

Across TCGA patient cohorts, GMEB1 mutation is significantly associated with the RNA expression of many other genes, with 207 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GMEB1-associated genes across cancer lineages are NPPB, RNA5SP415, and FAM96AP1. Each is linked with GMEB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GMEB1-to-partner and partner-to-GMEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPPB grouped by GMEB1-low versus GMEB1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMEB1→partner) and Y-score (partner→GMEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPPB →	+0.147	+2.623	.004	.003	3	3
UCEC	RNA5SP415 →	+0.728	+3.167	<.001	.003	3	2
CESC	FAM96AP1 →	+0.044	+5.000	<.001	.001	3	2
CESC	ELOCP27 →	+0.190	+3.189	.004	.003	3	2
COAD	HINT1P2 →	+0.538	+3.542	<.001	.005	3	2
LUSC	RNU6-607P →	+0.680	+6.309	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 207 associations by consensus.

NPPB by GMEB1 expression — SKCM

Explore this box plot interactively →