GMEB1

Across TCGA cell cohorts, GMEB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,199 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GMEB1-associated GO terms across cancer lineages are Negative regulation of chromosome condensation, Subtelomeric heterochromatin formation, and Regulation of protein sumoylation. Each is linked with GMEB1 in more than 14 cancer types. Because this analysis shows association rather than direction, both GMEB1-to-partner and partner-to-GMEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of chromosome condensation grouped by GMEB1-low versus GMEB1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GMEB1→partner) and Y-score (partner→GMEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of chromosome condensation →	+0.168	+1.201	<.001	<.001	3	15
BONE	Subtelomeric heterochromatin formation →	+0.184	+0.911	<.001	<.001	3	15
STOMACH	Regulation of protein sumoylation →	+0.114	+0.897	.001	.004	3	15
LARGE_INTESTINE	Centrosome cycle →	+0.087	+0.963	<.001	<.001	3	15
KIDNEY	Mitotic chromosome condensation →	+0.139	+0.867	<.001	<.001	3	14
SOFT_TISSUE	Centriole replication →	+0.103	+0.644	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,199 associations by consensus.

Negative regulation of chromosome condensation by GMEB1 expression — BONE

Explore this box plot interactively →