GMEB1

Across TCGA patient cohorts, GMEB1 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GMEB1-associated genes across cancer lineages are FoxM1, JNK2, and VHL. Each is linked with GMEB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GMEB1-to-partner and partner-to-GMEB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by GMEB1-low versus GMEB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GMEB1→partner) and Y-score (partner→GMEB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.295	+3.000	.048	.037	2	3
UCEC	JNK2 →	+0.396	+3.000	<.001	.037	3	1
UCEC	VHL →	-1.082	-3.000	.005	.037	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FoxM1 by GMEB1 expression — UCEC

Explore this box plot interactively →