GMEB1

Across TCGA pan-cancer cohorts, GMEB1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of GMEB1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where GMEB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types GMEB1 is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and PDAC are the cancer types where GMEB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GMEB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.259	<.001	10	view →
COAD	Male	III,IV	−0.450	<.001	9	view →
PDAC	All	II,III,IV	−0.320	.001	9	view →
LUAD	All	II,III,IV	−0.133	<.001	8	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

GMEB1–CCRCC

Open the CCRCC breakdown →