family with sequence similarity 98 member CGenealiases: []
Q-omics provides the consensus-scored FAM98C profile across patient tissues and cancer cell-line models. FAM98C expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, FAM98C is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, FAM98C RNA expression shows 18,648 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight BRCA, KIRC, and ACC as cancer lineages where FAM98C shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM98C — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM98C survival associations across molecular data types. FAM98C RNA expression shows survival associations in the most cancer types (24), followed by mutation status (1) and mass-spec protein abundance (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM98C RNA expression–survival associations across cancer types. High FAM98C expression shows unfavorable associations in ACC, PRAD and LGG, but favorable associations in BRCA, BLCA and HNSC. The BRCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify BRCA as the clearest survival context for FAM98C RNA expression.
This table summarizes FAM98C tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 7. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for FAM98C. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM98C shows lower tumor expression in KICH and higher tumor expression in KIRC, LIHC, BRCA, BLCA and COAD. The KIRC box plot shows higher FAM98C RNA expression in tumor versus normal tissue (log2 FC = +0.652, t-test p < 0.001).
This table shows molecular features associated with FAM98C in patient tissues and cancer cell lines. In patient samples, FAM98C shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM98C RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and UPPER_AERODIGESTIVE_TRACT.
