FAM98C

Across TCGA cell cohorts, FAM98C mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FAM98C-associated genes across cancer lineages are PTH, OR52A5, and IQCF3. Each is linked with FAM98C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM98C-to-partner and partner-to-FAM98C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by FAM98C-low versus FAM98C-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM98C→partner) and Y-score (partner→FAM98C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTH →	+0.045	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR52A5 →	+0.023	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.045	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.045	+4.887	<.001	.009	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR4F4 →	+0.019	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PTH by FAM98C expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →