FAM98C

Across TCGA pan-cancer cohorts, FAM98C RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM98C’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM98C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM98C is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where FAM98C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM98C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.652	<.001	12	view →
KICH	Female	All	−1.098	<.001	10	view →
LIHC	Female	II,III,IV	+1.002	<.001	9	view →
BRCA	All	III,IV	+0.590	.003	6	view →
BLCA	All	All	+0.551	.008	6	view →
COAD	All	II,III,IV	+0.303	.004	4	view →
CHOL	All	All	+1.572	<.001	3	view →
LUSC	All	All	+0.392	.001	3	view →
PAAD	All	All	+0.617	.045	2	view →
ESCA	All	All	+0.541	.004	2	view →
KIRP	All	II,III,IV	+0.410	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM98C–KIRC

Open the KIRC breakdown →