FAM98C

Across TCGA pan-cancer cohorts, FAM98C mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FAM98C data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM98C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM98C expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where FAM98C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.850	0.503	.004	17	view →
LUAD	OS	Tertile	II,III,IV	0.350	0.799	.006	16	view →
LSCC	DFS	Quartile	III,IV	0.633	0.984	.015	14	view →
HNSC	OS	Quartile	II,III,IV	0.770	0.939	.005	10	view →
PDAC	OS	Tertile	II,III,IV	0.648	0.438	.024	9	view →
UCEC	OS	Median	III,IV	1.000	0.518	.027	4	view →
GBM	OS	Quartile	All	0.928	0.783	.028	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FAM98C–CCRCC (DFS)

Open the CCRCC breakdown →