family with sequence similarity 234 member AGenealiases: C16orf9 · ITFG3 · gs19
Q-omics provides the consensus-scored FAM234A profile across patient tissues and cancer cell-line models. FAM234A expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FAM234A is differentially expressed in 13, with the highest sampling consensus in KIRP. Additionally, FAM234A RNA expression shows 18,674 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, KIRP, and ACC as cancer lineages where FAM234A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM234A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM234A survival associations across molecular data types. FAM234A RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM234A RNA expression–survival associations across cancer types. High FAM234A expression shows unfavorable associations in KIRC, ACC, LGG, UCS, CHOL and LIHC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FAM234A RNA expression.
This table summarizes FAM234A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRP for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for FAM234A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM234A shows higher tumor expression in KIRP, LIHC, KIRC, HNSC, LUSC and UCEC. The KIRP box plot shows higher FAM234A RNA expression in tumor versus normal tissue (log2 FC = +1.787, t-test p < 0.001).
This table shows molecular features associated with FAM234A in patient tissues and cancer cell lines. In patient samples, FAM234A shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM234A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in LIVER and CNS.
