FAM234A

Across TCGA pan-cancer cohorts, FAM234A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM234A data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher FAM234A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM234A expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where FAM234A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.486	0.730	.014	6	view →
HNSC	OS	Median	All	0.633	0.823	.022	4	view →
LUAD	DFS	Median	II,III,IV	0.495	0.761	.028	3	view →
GBM	OS	Median	All	0.866	0.766	.030	1	view →
LSCC	OS	Median	II,III,IV	1.000	0.833	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM234A–CCRCC (DFS)

Open the CCRCC breakdown →