FAM234A

Across TCGA pan-cancer cohorts, FAM234A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM234A data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher FAM234A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM234A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and ACC are the cancer types where FAM234A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.579	0.949	<.001	12	view →
UCEC	OS	Median	All	1.000	0.651	.016	10	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
LIHC	DFS	Median	All	0.155	0.555	.025	6	view →
STAD	OS	Median	All	0.142	0.545	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM234A–BRCA (DFS)

Open the BRCA breakdown →