FAM234A

Across TCGA cell cohorts, FAM234A mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM234A-associated genes across cancer lineages are C1QC, FXYD4, and RAI2. Each is linked with FAM234A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM234A-to-partner and partner-to-FAM234A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QC grouped by FAM234A-low versus FAM234A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM234A→partner) and Y-score (partner→FAM234A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C1QC →	+0.019	+5.228	<.001	.005	3	2
SKIN	FXYD4 →	+0.161	+4.977	<.001	.007	3	1
BLOOD_Leukemia	RAI2 →	+0.088	+4.428	.003	.001	3	1
BLOOD_Leukemia	IL21 →	+0.032	+4.786	<.001	<.001	3	1
BLOOD_Leukemia	DCLK3 →	+0.161	+3.769	.003	.008	3	1
BLOOD_Leukemia	TACR3 →	+0.028	+4.060	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C1QC by FAM234A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →