family with sequence similarity 120 member AGenealiases: C9orf10 · HBVPTPAP · OSSA
Q-omics provides the consensus-scored FAM120A profile across patient tissues and cancer cell-line models. FAM120A expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, FAM120A is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, FAM120A protein abundance shows 24,594 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRC, HNSC, and BRCA as cancer lineages where FAM120A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM120A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM120A survival associations across molecular data types. FAM120A RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3) and mass-spec protein abundance (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM120A RNA expression–survival associations across cancer types. High FAM120A expression shows unfavorable associations in ACC, LGG, UCS, UVM and HNSC, but favorable associations in KIRC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for FAM120A RNA expression.
This table summarizes FAM120A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for FAM120A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM120A shows higher tumor expression in HNSC, LIHC, BRCA, LUSC, LUAD and STAD. The HNSC box plot shows higher FAM120A RNA expression in tumor versus normal tissue (log2 FC = +0.951, t-test p < 0.001).
This table shows molecular features associated with FAM120A in patient tissues and cancer cell lines. In patient samples, FAM120A shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, FAM120A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
